KB-1084

2M24-hIgG1

12103

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Background of 2M24-hIgG1

Dectin-1 belongs to the hemITAM family and can be found in the plasma membrane of various myeloid cells, including DCs, monocytes, and macrophages, as well as B cells. Activation of dectin-1 by fungal cell wallβ-glucans stimulates phagocytosis, the production of ROS, and NFkB-mediated cytokine secretion. In contrast to the TLR pathways, dectin-1-mediated NFkB signaling is driven by Syk recruitment and the subsequent formation of a multiprotein signaling complex, the CARD9 signalosome.

Specifications

Catalog Number	KB-1084
Antibody Name	2M24-hIgG1
Isotype	Human IgG1,kappa
FC Muations	Wild Type
Target	Dectin-1
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	ELISA \| FACS
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Netea MG, Domínguez-Andrés J, Barreiro LB, Chavakis T, Divangahi M, Fuchs E, et al. Defining Trained Immunity and its Role in Health and Disease. Nat Rev Immunol (2020) 20:375–88.
Sancho D, Reis e Sousa C. Signaling by Myeloid C-Type Lectin Receptors in Immunity and Homeostasis. Annu Rev Immunol (2012) 30:491–529.