KB-1125

JNJ372-EGFR-hIgG1

12133

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Background of JNJ372-EGFR-hIgG1

JNJ372-EGFR-hlgG1, a high affinity-specific humanized IgG1 antibody against EGFR.The Epidermal Growth Factor Receptor (EGFR) is frequently expressed at elevated levels in different forms of cancer and expression often correlates positively with cancer progression and poor prognosis. EGFR is responsible for the maintenance and functions of cancer stem cells (CSCs), including stemness, metabolism, immunomodulatory-activity, dormancy and therapy-resistance. In a variety of cancer cells, scientists have found high expression of EGFR.

Specifications

Catalog Number	KB-1125
Antibody Name	JNJ372-EGFR-hIgG1
Isotype	Human IgG1,kappa
FC Muations	Wild Type
Target	EGFR
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	ELISA\|FACS\|KD
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Talukdar Sarmistha,Emdad Luni,Das Swadesh K et al. EGFR: An essential receptor tyrosine kinase-regulator of cancer stem cells.[J] .Adv Cancer Res, 2020, 147: 161-188.