KB-1145

SAR442257-CD28-hIgG4-S228P

12151

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Background of SAR442257-CD28-hIgG4-S228P

SAR442257 (CD38/CD28xCD3) is a trispecific T cell engager designed for the treatment of multiple myeloma (MM). Its cytotoxic activity and anti-tumor efficacy is dependent on the expression of CD38 by malignant plasma cells and the recruitment and activation of T cells via CD3 and CD28.

Specifications

Catalog Number	KB-1145
Antibody Name	SAR442257-CD28-hIgG4-S228P
Isotype	Human IgG4-S228P, kappa
FC Muations	S228P
Target	CD28
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	ELISA\|FACS
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Edmead CE, Lamb JR, Hoyne GF. The T cell surface protein, CD28. Int J Biochem Cell Biol. 1997 Aug-Sep;29(8-9):1053-7.
Ma BY, Mikolajczak SA, Yoshida T, Yoshida R, Kelvin DJ, Ochi A. CD28 T cell costimulatory receptor function is negatively regulated by N-linked carbohydrates. Biochem Biophys Res Commun. 2004 Apr 23;317(1):60-7.