KB-1163

1G4V2-hIgG1

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Home » 1G4V2-hIgG1

Background of 1G4V2-hIgG1

The lymphocyte antigen 6 complex locus G6D (LY6G6D) is a member of the lymphocyte antigen 6 superfamily (Ly-6SF). LY6G6D is positioned within the MHC class III region on chromosome 6, wherein it encodes a polypeptide comprising 133 amino acid residues with an approximate molecular weight of 13.7 kDa. Genentech, an innovative leader in large molecule pharmaceuticals, has developed a anti-LY6G6D/CD3 bispecific antibody (LY6G6D-TDB) for colorectal cancer (CRC) treatment in its earlier days. In mouse xenograft tumor models, LY6G6D-TDB shows anti-tumor efficacy as a single agent against established colorectal tumors. 1G4V1-hIgG1 is a monoclonal antibody that only binds to LY6G6D.

Specifications

Catalog NumberKB-1163
Antibody Name1G4V2-hIgG1
IsotypeHuman IgG1,kappa
FC MuationsWild Type
TargetLY6G6D
Species ReactivityHuman
Host Cell LineEXPI CHO
Purification MethodAffinity purified
Concentration>2 mg/mL
Formulation50 mM sodium citrate,150mM NaCl,pH5.5
Purity>95% by SDS-PAGE and SEC-HPLC
ValidationELISA
Endotoxin Level<0.2 EU/mg as determined by the LAL method
Sterility0.2μm filtered
StorageIt is recommended that the protein should be aliquoted for optimal storage.
Avoid repeated freeze-thaw cycles.
StabilityStable for twelve months from date of receipt when stored at -20°C to -80°C;
Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

  1. Novel Anti-LY6G6D/CD3 T-Cell–Dependent Bispecific Antibody for the Treatment of Colorectal Cancer
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