KB-1181

MOR07692-hIgG1

12185

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Background of MOR07692-hIgG1

MST1R (Macrophage-stimulating protein receptor), is a receptor tyrosine kinase belonging to the tumor necrosis factor receptor family. Overactivation of MST1R in cancer is associated with tumorigenesis, progression, and metastasis. Studies have shown that MST1R is highly expressed in various tumors, including lung cancer, breast cancer, gastric cancer, colorectal cancer, and others. Therefore, MST1R has emerged as a potential target for cancer therapy. Researchers are actively developing MST1R inhibitors to suppress its activity, thereby interfering with processes such as tumor cell proliferation, migration, and invasion.

Specifications

Catalog Number	KB-1181
Antibody Name	MOR07692-hIgG1
Isotype	Human IgG1,kappa
FC Muations	Wild Type
Target	MST1R
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	FACS
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Catenacci D V T , Cervantes G , Yala S ,et al.RON (MST1R) is a novel prognostic marker and therapeutic target for gastroesophageal adenocarcinoma[J].Cancer Biology & Therapy, 2011, 12(1):9-46.
Catenacci D V T , Henderson L , Cervantes G ,et al.Abstract LB-124: RON (MST1R) is a novel prognostic marker and therapeutic target for gastroesophageal adenocarcinoma[J].Cancer Research, 2011, 71(8 Supplement):9-46.