KB-1235

GEN1042-CD137-hIgG1

12235

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Background of GEN1042-CD137-hIgG1

4-1BB (CD137) is a costimulatory TNFR expressed on immune cells, including T cells, natural killer cells and monocytes. While naïve T cells lack 4-1BB expression, the receptor is upregulated on T-cell receptor engagement. Crosslinking of 4-1BB activates the MAPK and NF-κB signaling pathways and enhances T-cell proliferation and cytokine production, enhances cytotoxic T-cell effector functions and prevents activation-induced cell death of T cells. GEN1042 (DuoBody®-CD40x4-1BB) is an investigational, novel, agonistic, bispecific antibody that combines targeting and conditional activation of CD40 and 4-1BB on immune cells for priming and (re-) activation of tumor-specific immune responses. GEN1042-CD137-hIgG1 is a monoclonal antibody that only targets CD137.

Specifications

Catalog Number	KB-1235
Antibody Name	GEN1042-CD137-hIgG1
Isotype	Human IgG1,kappa
Target	CD137
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	ELISA
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity
Immunotherapy targeting 4-1BB: mechanistic rationale, clinical results, and future strategies.