KP-3001

Human-CD3-antibody-OKT3

12305

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Background of Human-CD3-antibody-OKT3

Hybridoma cell line (OKT3), is a cell line used to produce IgG2a monoclonal antibodies against CD3 antigen of human T lymphocyte cells. OKT3 is a monoclonal antibody targeted at the CD3 receptor located on the surface of T cells. Being approved by the FDA in 1985, it is also an immunosuppressant drug given to reduce acute rejection in patients with organ transplants, making it the first monoclonal antibody to be approved anywhere as a drug for humans.

Specifications

Catalog Number	KP-3001
Antibody Name	Human-CD3-antibody-OKT3
Isotype	Mouse-IgG2a, kappa
Target	CD3
Species Reactivity	Human
Host Cell Line	EXPI-CHO
Purification Method	Affinity purified
Concentration	>2mg/mL
Formulation	20mM sodium citrate,150mM NaCl, pH5.5
Purity	>95% by SDS-PAGE and SEC-SEC-HPLC
Validation	SDS-PAGE \| SEC-HPLC \| ELISA \| FACS \| Function assay \| KD
Endotoxin Level	<0.5 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Pauline Wimberger Wei Xiang &Doris Mayr et al. Efficient tumor cell lysis by autologous, tumor-resident T lymphocytes in primary ovarian cancer samples by an EP-CAM-/CD3-bispecific antibody. IJC. Volume105, Issue2(2003).