293T-ROR2-KO-2C2-Cell-Line

Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a receptor for the Wnt5a ligand that plays a major role during embryonic development. ROR2 expression is strongly downregulated after birth but was shown to express aberrantly in cancer as well as in other pathological conditions in the adult. In cancer, ROR2 possesses a dual role by either suppressing or promoting tumor progression in different tumor types. For example, ROR2 has a tumor suppressive function in endometrial and colon cancer, in medulloblastoma, and hepatocellular and gastric carcinoma. In several other tumor types including cancers from the breast, prostate, and ovary among others, ROR2 promotes cancer. The underlying reasons for this discrepancy have not been elucidated and ROR2 has been considered alternatively an oncogene or a tumor suppressor gene depending on the tumor type. Interestingly, ROR2 exerts these dual functions by regulating the same biological processes in opposite ways. For instance, the anti- and pro-tumoral function of ROR2 have been associated with the inhibition or stimulation of cell proliferation, respectively. Similarly, ROR2 was shown to either enhance or inhibit cell migration and invasion.