KB-1090

3a23-hIgG1

33663

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Background of 3a23-hIgG1

SLC34A2, also known as Sodium-dependent phosphate transport protein 2B, is highly expressed in the lung. It is also detected in the pancreas, kidney, small intestine, ovary, testis, prostate, and mammary gland. In the lung, it is primarily found in alveolar type II cells and not in bronchiolar epithelium. This protein may play a role in actively transporting phosphate into cells through Na+ cotransport. Additionally, it is believed to be the primary phosphate transport protein in the intestinal brush border membrane. Furthermore, it may have a role in the synthesis of surfactant in the alveoli of the lungs.

Specifications

Catalog Number	KB-1090
Antibody Name	3a23-hIgG1
Isotype	Human IgG1,kappa
FC Muations	Wild Type
Target	SLC34A2
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	FACS
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Wang, Y., Yang, W., Pu, Q. et al. The effects and mechanisms of SLC34A2 in tumorigenesis and progression of human non-small cell lung cancer. J Biomed Sci 22, 52 (2015).
A.K. Nurgalieva, V.E. Popov, V.S. Skripova, L.F. Bulatova, D.V. Savenkova, R.A. Vlasenkova, S.Z. Safina, E. Zh Shakirova, V.V. Filonenko, M.V. Bogdanov, R.G. Kiyamova,Sodium-dependent phosphate transporter NaPi2b as a potential predictive marker for targeted therapy of ovarian cancer,Biochemistry and Biophysics Reports,Volume 28,2021,101104,ISSN 2405-5808.