KB-1211

hu9B12-hIgG1

33685

Background of hu9B12-hIgG1

Lymphocyte antigen 6E (LY6E), also referred to as RIG-E, SCA2, and TSA1, is a cell surface protein anchored by GPI. It plays a crucial role in regulating the proliferation, differentiation, and activation of T-lymphocytes. LY6E interacts with CD3Z/CD247, a component of the T-cell receptor (TCR) signaling pathway, at the plasma membrane, thereby modulating the phosphorylation of CD3Z/CD247. This interaction restricts the entry of various human coronaviruses, including SARS-CoV, MERS-CoV, and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. Additionally, LY6E acts as the primary receptor for syncytin-A (SynA), contributing to the normal fusion of syncytiotrophoblast layer I (SynT-I) and the proper development of both fetal and maternal vasculatures within the placenta. It may also function as a modulator of nicotinic acetylcholine receptors (nAChRs) activity.

Specifications

Catalog Number	KB-1211
Antibody Name	hu9B12-hIgG1
Isotype	Human IgG1,kappa
Target	LY6E
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	ELISA\|FACS
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

A novel thymocyte marker discriminating immature from mature thymocyte subsets. J Immunol. 1992.
Mao M, Yu M, Tong JH et al. RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the difffferentiation of acute promyelocytic leukemia cell. Proc Natl Acad Sci U S A. 1996.