KB-1333

Mirvetuximab

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Home » Antibodies » Mirvetuximab

Background of Mirvetuximab

Mirvetuximab represents a novel category of cancer therapy recognized as an antibody-drug conjugate. Its mode of action revolves around targeting folate receptor alpha (FRα), a protein notably abundant on the surface of various cancer cells, notably ovarian cancer cells. Upon binding to FRα, Mirvetuximab infiltrates the cancer cell, releasing a potent chemotherapy drug directly into its core. Subsequently, the administered drug induces cell death within the cancerous cells. This precise mechanism enables the delivery of concentrated chemotherapy doses specifically to cancer cells, thereby mitigating harm to healthy cells.

Specifications

Catalog NumberKB-1333
Antibody NameMirvetuximab
IsotypeHuman IgG1,kappa
FC MuationsK447Del
TargetFOLR1
Species ReactivityHuman
Host Cell LineEXPI CHO
Purification MethodAffinity purified
Concentration>2 mg/mL
Formulation50 mM sodium citrate,150mM NaCl,pH5.5
Purity>95% by SDS-PAGE and SEC-HPLC
ValidationELISA
Endotoxin Level<0.2 EU/mg as determined by the LAL method
Sterility0.2μm filtered
StorageIt is recommended that the protein should be aliquoted for optimal storage.
Avoid repeated freeze-thaw cycles.
StabilityStable for twelve months from date of receipt when stored at -20°C to -80°C;
Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

  1. Elahere demonstrates overall survival benefit in the phase 3 MIRASOL trial in patients with FRα-positive platinum-resistant ovarian cancer. News release. ImmunoGen Inc. May 3, 2023. Accessed May 3, 2023. https://investor.immunogen.com/news-releases/news-release-details/elaherer-demonstrates-overall-survival-benefit-phase-3-mirasol.
  2. ImmunoGen announces FDA accelerated approval of Elahere (mirvetuximab soravtansine-gynx) for the treatment of platinum-resistant ovarian cancer. News release. ImmunoGen Inc. November 14, 2022. Accessed May3,2023.https://investor.immunogen.com/news-releases/news-release-details/immunogen-announces-fda-accelerated-approval-elaheretm
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