KB-1200

REGN7075-EGFR-hIgG1

44864

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Background of REGN7075-EGFR-hIgG1

EGFR (Epidermal Growth Factor Receptor) is a protein that plays a crucial role in the regulation of cell growth, survival, proliferation, and differentiation. It is a member of the ErbB family of receptor tyrosine kinases and is primarily involved in signaling pathways that control cell division and survival. EGFR is activated by binding to its ligands, such as epidermal growth factor (EGF), leading to receptor dimerization and activation of downstream signaling pathways, including the MAPK and PI3K pathways, which promote cell proliferation. Due to its significant role in cancer biology, EGFR has become a major target for cancer therapies.

Specifications

Catalog Number	KB-1200
Antibody Name	REGN7075-EGFR-hIgG1
Isotype	Human IgG1, kappa
FC Muations	Wild Type
Target	EGFR
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	20mM sodium citrate,150mM NaCl, pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	ELISA
Endotoxin Level	<0.2EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C;Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Tao R.-H., Maruyama I.N. All EGF(ErbB) receptors have preformed homo- and heterodimeric structures in living cells. J. Cell Sci. 2008;121:3207–3217.
Hoffmann I. Activation of ErbB2 receptor tyrosine kinase supports invasion of endothelial cells by Neisseria meningitidis. J. Cell Biol. 2001;155:133–144.
Torp S.H. Epidermal growth factor receptor expression in human gliomas. Cancer Immunol. Immunother. 1991;33:61–64.
Oda Y. Expression of growth factors and their receptors in human osteosarcomas. Immunohistochemical detection of epidermal growth factor, platelet-derived growth factor and their receptors: its correlation with proliferating activities and p53 expression. Gen. Diagn. Pathol. 1995;141:97–103.
Donnenberg A.D. The cell-surface proteome of cultured adipose stromal cells. Cytometry. 2015;87:665–674.
Scheving L.A. Loss of hepatocyte ERBB3 but not EGFR impairs hepatocarcinogenesis. Am. J. Physiol. Gastrointest. Liver Physiol. 2015;309:G942–G954.
Brea M.S. Epidermal growth factor receptor silencing blunts the slow force response to myocardial stretch. J. Am. Heart Assoc. 2016;5:e004017.