KB-1053

AMG110-Epcam-hIgG1

45113

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Background of AMG110-Epcam-hIgG1

Epithelial cell adhesion molecule (EpCAM), also referred to as CD326, is a transmembrane glycoprotein that facilitates Ca2+-independent homotypic cell-cell adhesion in epithelial tissues. Beyond its role in adhesion, EpCAM is integral to various cellular processes including signaling, migration, proliferation, and differentiation. Notably, it possesses oncogenic potential by upregulating key genes such as c-myc, e-fabp, and cyclins A and E. EpCAM is uniquely expressed in epithelial tissues and epithelial-derived neoplasms, making it a valuable diagnostic marker for several cancers. Its involvement in tumorigenesis and metastasis suggests that EpCAM could serve not only as a prognostic marker but also as a target for immunotherapeutic strategies.

Specifications

Catalog Number	KB-1053
Antibody Name	AMG110-Epcam-hIgG1
Isotype	Human IgG1,kappa
FC Muations	S228P/L235E
Target	Epcam
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	ELISA\|KD
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Litvinov SV, Velders MP, Bakker HA, Fleuren GJ, Warnaar SO (April 1994). "Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule". The Journal of Cell Biology. 125 (2): 437–46.
Osta WA, Chen Y, Mikhitarian K, Mitas M, Salem M, Hannun YA, et al. (August 2004). "EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy". Cancer Research. 64 (16): 5818–24.