KB-1219

REGN7257-hIgG4-S228P

45339

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Background of REGN7257-hIgG4-S228P

The common γ chain (γc; IL-2RG) is a subunit of the interleukin (IL) receptors for the γc cytokines IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. REGN7257 is a γc cytokine receptor antibody. REGN7257 binds with high affinity to IL-2RG and potently blocks signaling of all γc cytokines. Using REGN7257, we showed that γc cytokines drive T cell–mediated disease in mouse models of graft-versus-host disease (GVHD) and multiple sclerosis by affecting multiple aspects of the pathogenic response.

Specifications

Catalog Number	KB-1219
Antibody Name	REGN7257-hIgG4-S228P
Isotype	Human IgG4-S228P, kappa
FC Muations	S228P
Target	IL2RG
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	ELISA
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Audrey Le Floc’h et al. ,Blocking common γ chain cytokine signaling ameliorates T cell–mediated pathogenesis in disease models.Sci. Transl. Med.15,eabo0205(2023).
REGN7257 in Adult Patients With Severe Aplastic Anemia That Is Refractory to or Relapsed on Immunosuppressive Therapy-NCT04409080