KB-1376

PRA023-hIgG1

45592

Background of PRA023-hIgG1

TL1A, also known as TNFSF15, is a member of the tumor necrosis factor (TNF) family. It is expressed by monocytes, macrophages, dendritic cells (DCs), synovial fibroblasts, and endothelial cells in response to stimulation by cytokines, immune complexes, and microorganisms. PRA023 is an IgG1 humanized monoclonal antibody designed to block tumor necrosis factor-like ligand 1A (TL1A). It binds both soluble and membrane-associated human TL1A with high affinity and specificity. PRA023 holds significant potential for improving outcomes in patients with moderate-to-severe inflammatory bowel disease (IBD) who are predisposed to increased TL1A expression.

Specifications

Catalog Number	KB-1376
Antibody Name	PRA023-hIgG1
Isotype	Human IgG1,kappa
Target	TL1A
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	ELISA
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Migone, T.S. et al. TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Immunity 16, 479–492 (2002).
Shih, D.Q. et al. Microbial induction of inflammatory bowel disease associated gene TL1A (TNFSF15) in antigen presenting cells. Eur. J. Immunol. 39, 1–12 (2009).