KB-1427

PPMX-T002-hIgG1

45678

Home » Antibodies » PPMX-T002-hIgG1

Background of PPMX-T002-hIgG1

CDH3, recognized as Cadherin-3 or P-Cadherin, is a member of the cell adhesion molecule family. Cadherin, a transmembrane glycoprotein, predominantly serves in cell adhesion, preserving the integrity of normal tissue structures. While CDH3 exhibits limited expression in normal tissues, its presence elevates significantly in numerous malignant tumors, including lung cancer, breast cancer, gastric cancer, and ovarian cancer, correlating with adverse prognostic outcomes. Functionally, CDH3 orchestrates the activity of the Wnt/β-catenin signaling pathway, thereby engaging in the regulation of tumor cell proliferation and the facilitation of tumor growth.

Specifications

Catalog Number	KB-1427
Antibody Name	PPMX-T002-hIgG1
Isotype	Human IgG1,kappa
Target	CDH3
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	ELISA
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Schmeiser K, Grand RJ (Apr 1999). "The fate of E- and P-cadherin during the early stages of apoptosis". Cell Death and Differentiation. 6 (4): 377–86.
Lehtonen S, Lehtonen E, Kudlicka K, Holthöfer H, Farquhar MG (Sep 2004). "Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin". The American Journal of Pathology. 165 (3): 923–36.