KB-1470

AMG509-STEAP1-hIgG1

45750

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Background of AMG509-STEAP1-hIgG1

STEAP1 belongs to the STEAP family of metalloreductases that can form homotrimers or heterotrimers with other STEAP proteins. STEAP1 has an established functional role in promoting cancer cell proliferation, invasion, and epithelial-to-mesenchymal transition.

Specifications

Catalog Number	KB-1470
Antibody Name	AMG509-STEAP1-hIgG1
Isotype	Human IgG1,kappa
FC Muations	Wild Type
Target	STEAP1
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	FACS
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Grunewald, T. G. et al. High STEAP1 expression is associated with improved outcome of Ewing’s sarcoma patients. Ann. Oncol. Off. J. Eur. Soc. Med. Oncol. 23, 2185–2190 (2012).