KB-1261

XENP018087-hIgG1

47484

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Background of XENP018087-hIgG1

SSTR2 is a G-protein coupled receptor integral to cellular signaling and the regulation of somatostatin, a peptide hormone with diverse biological functions. SSTR2 is pivotal in modulating the secretion of growth hormone, insulin, and gastric secretions. SSTR2 is predominantly expressed in tissues such as the pancreas, brain, and kidneys. Notably, SSTR2 is overexpressed in various tumors, making it a critical target for diagnostic imaging and targeted therapies in neuroendocrine tumors, thyroid cancer, breast cancer, and other malignancies.

Specifications

Catalog Number	KB-1261
Antibody Name	XENP018087-hIgG1
Isotype	Human-IgG1, kappa
FC Muations	Wild Type
Target	SSTR2
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	FACS
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	Liquid nitrogen immediately upon receiving
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C;Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Yu B, Zhang Z, Song H, Chi Y, Shi C, Xu M (April 2017). Clinical Importance of Somatostatin Receptor 2 (SSTR2) and Somatostatin Receptor 5 (SSTR5) Expression in Thyrotropin-Producing Pituitary Adenoma (TSHoma). Medical Science Monitor. 23: 1947–1955.
Kennedy JW, Dluhy RG (1997). The biology and clinical relevance of somatostatin receptor scintigraphy in adrenal tumor management. The Yale Journal of Biology and Medicine. 70 (5–6): 565–75.