KB-1674

Zanidatamab

53268

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Background of Zanidatamab

HER2 receptors are a collection of proteins distributed throughout the body's cells. They are found mostly on epithelial surfaces, where they bind to numerous growth factors and transfer signals into the cell via the signal transduction pathways. These cells perform several roles such as cell growth regulation, motility, adhesion, epithelial proliferation, and differentiation. Zanidatamab is an IgG1-like antibody target and binds to two different binding domains ECD4 (juxtamembrane) and ECD2 (dimerization) extracellular domains on HER2 receptor at the same time.

Specifications

Catalog Number	KB-1674
Antibody Name	Zanidatamab
Isotype	Human IgG1,kappa (one arm)
FC Muations	HC1: C220S/T350V/T366L/K392L/T394W/K447Del HC2:L351Y/F405A/Y407V/K447Del
Target	HER2
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	FACS
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Murphrey MB, Quaim L, Rahimi N, Varacallo MA. Biochemistry, Epidermal Growth Factor Receptor. 2023 Dec 3.
Tarantino P, Morganti S, Curigliano G. Targeting HER2 in breast cancer: new drugs and paradigms on the horizon. Explor Target Antitumor Ther. 2021;2(2):139-155.
Kanwal W, Narjis K, Musani S, Nancy F, Qureshi L, Mudasir M, Naseem R, Tooba F, Yousuf J, Farhan K, Javed H, Eljack MMF. Exploring Zanidatamab's efficacy across HER2-positive Malignancies: a narrative review. BMC Cancer. 2025 Mar 1;25(1):382.