KB-1677

Amlitelimab

53270

Background of Amlitelimab

Ky1005-hIgG4 is a human monoclonal antibody that targets OX40L, a key regulator of the immune system. Ky1005-hIgG4 is designed to rebalance the immune system by blocking inappropriate activation and proliferation of pro-inflammatory effector T cells and promoting expansion of anti-inflammatory regulatory T cells, without broad suppression of the immune system.

Specifications

Catalog Number	KB-1677
Antibody Name	Amlitelimab
Isotype	Human IgG4-S228P,kappa
FC Muations	S228P/L235E
Target	OX40L
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	ELISA
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Munks, M.W., Mourich, D.V., Mittler, R.S., Weinberg, A.D. & Hill, A.B. 4-1BB and OX40 stimulation enhance CD8 and CD4 T-cell responses to a DNA prime, poxvirus boost vaccine. Immunology 112, 559-566 (2004).
Zaini, J. et al. OX40 ligand expressed by DCs costimulates NKT and CD4+ Th cell antitumor immunity in mice. J. Clin. Investig. 117, 3330-3338 (2007).
Melero, I., Hirschhorn-Cymerman, D., Morales-Kastresana, A., Sanmamed, M.F. & Wolchok, J.D. Agonist antibodies to TNFR molecules that costimulate T and NK cells. Clin. Cancer Res. 19, 1044-1053 (2013).