CHOK1-FGFR2b-EGFP-Middle Cell Line

FGFR2 (Fibroblast Growth Factor Receptor 2) is a Protein Coding gene. The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.Green fluorescent protein is a protein composed of about 238 amino acids, which can be excited from blue light to ultraviolet light, and emits green fluorescence. Green fluorescent protein (GFP), commonly referred to as enhanced green fluorescent protein (EGFP), is a widely used variant of wild-type green fluorescent protein (wt-GFP). EGFP, or Enhanced Green Fluorescent Protein, and GFP, which stands for Green Fluorescent Protein. EGFP is a GFP mutant line, and the most widely used is the mutant of GFP: enhanced green fluorescent protein (EGFP) (64-bit phenylpropylene bright), which emits fluorescence intensity more than 6 times greater than that of GFP.