KB-1735

10F9G2-mIgG2a-PGLALA

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Home » Antibodies » 10F9G2-mIgG2a-PGLALA

Background of 10F9G2-mIgG2a-PGLALA

10F9G2 monoclonal antibody can bind to mouse PD-L1 (programmed death ligand 1). Programmed cell death 1 ligand 1 (PD-L1), also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1), is encoded by the CD274 gene. Recent years, a total of 5 PD-1/PD-L1 antibody drugs have been approved, including 2 PD-1 inhibitors and 3 PD-L1 inhibitors, with indications involving non-small cell lung cancer, gastric cancer, melanoma kidney cancer, etc., and new indications will be approved one after another. 10F9G2 antibodies have been shown to block the interaction between PD-L1 and PD-1 and PD-L1 and B7-1 (CD80), promising for cancer treatment.

Specifications

Catalog NumberKB-1735
Antibody Name10F9G2-mIgG2a-PGLALA
IsotypeMouse IgG2a,kappa
TargetMouse PDL1
Species ReactivityMouse
Host Cell LineEXPI CHO
Purification MethodAffinity purified
Concentration>2 mg/mL
Formulation50 mM sodium citrate,150mM NaCl,pH5.5
Purity>95% by SDS-PAGE and SEC-HPLC
ValidationELISA
Endotoxin Level<0.2 EU/mg as determined by the LAL method
Sterility0.2μm filtered
StorageIt is recommended that the protein should be aliquoted for optimal storage.
Avoid repeated freeze-thaw cycles.
StabilityStable for twelve months from date of receipt when stored at -20°C to -80°C;
Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

  1. Bylicki, Olivier; Paleiron, Nicolas; Rousseau-Bussac, Gaelle; Chouaid, Christos (2018). New PDL1 inhibitors for non-small cell lung cancer: focus on pembrolizumab. OncoTargets and Therapy, Volume 11(), 4051–4064. doi:10.2147/OTT.S154606.
  2. Basile, Debora; Pelizzari, Giacomo; Vitale, Maria Grazia; Lisanti, Camilla; Cinausero, Marika; Iacono, Donatella; Puglisi, Fabio (2018). Atezolizumab for the treatment of Breast Cancer. Expert Opinion on Biological Therapy, (), 14712598.2018.1469619–. doi:10.1080/14712598.2018.1469619.
  3. Siyu Wang;Yue Song;Kunxia Cao;Lingxiao Zhang;Xuedong Fang;Fangfang Chen;Shouhua Feng;Fei Yan; (2021). Photothermal therapy mediated by gold nanocages composed of anti-PDL1 and galunisertib for improved synergistic immunotherapy in colorectal cancer . Acta Biomaterialia, (), –. doi:10.1016/j.actbio.2021.07.051 
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