KB-1667

huNb24-5-hFCm29

60289

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Background of huNb24-5-hFCm29

Single-domain antibody (nanobody, Nb) is heavy chain single-domain antibody VHH (variable domain of heavy chain antibody). Camels have a heavy-chain antibody (HCAb) that naturally lacks the light chain. The single-domain antibody obtained by cloning its variable region, is consisted of only one heavy chain variable region and is the smallest unit of fully functional stable binding antigen at present. Single-domain antibodies have the characteristics of high stability, good aqueous solubility, simple humanization, high targeting and strong penetration, and play a huge role in immune experiment, diagnosis and treatment.

Specifications

Catalog Number	KB-1667
Antibody Name	huNb24-5-hFCm29
Isotype	Human IgG1
FC Muations	C220S
Target	VEGFA
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	ELISA
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

EP4032905A1-ANTI-VEGF SINGLE-DOMAIN ANTIBODY AND USE THEREOF