KB-1685

Siltuximab

60291

Background of Siltuximab

Siltuximab (CNTO 328) is an anti-interleukin-6 (IL-6) chimeric monoclonal antibody approved for the treatment of patients with human immunodeficiency virus (HIV) negative and human herpesvirus-8 (HHV-8) negative multicentric Castleman’s disease (MCD) by the US Food and Drug Administration in 2014 with the dose of 11 mg/kg over 1 hour intravenous infusion every 3 weeks. Siltuximab has been confirmed to neutralize the IL-6 effect in a number of human malignancies, such as MCD, multiple myeloma (MM), myelodysplastic syndrome (MDS), prostate cancer, ovarian cancer, and lung cancer, and it also can reduce cancer-related anorexia and cachexia.

Specifications

Catalog Number	KB-1685
Antibody Name	Siltuximab
Isotype	Human IgG1,kappa
FC Muations	Wild Type
Target	IL6
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	ELISA
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Chen R, Chen B. Siltuximab (CNTO 328): a promising option for human malignancies. Drug Des Devel Ther. 2015 Jul 2;9:3455-8.