Survivin aliases is BIRC5. BIRC5 (Baculoviral IAP Repeat Containing 5) is a Protein Coding gene.This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.P53 mutations are universal across cancer types.This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants.Ras k 1 is a major allergen from the Indian mackerel (Rastrelliger kanagurta). It belongs to the parvalbumin family, a calcium-binding protein highly conserved in fish muscles. With a molecular weight of ~11.3 kDa, Ras k 1 is heat-stable and responsible for IgE-mediated allergic reactions in fish-sensitive individuals.
