KB-1035

1452C11-mIgG1

12069

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Background of 1452C11-mIgG1

CD3 is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). The anti-mCD3 145-2C11 mAb is commonly used for cytometry detection and in vivo depletion of the T cell population.

Specifications

Catalog Number	KB-1035
Antibody Name	1452C11-mIgG1
Isotype	Mouse IgG1,kappa
FC Muations	Wild Type
Target	Mouse-CD3
Species Reactivity	Mouse
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	ELISA\|FACS
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Hooks MA, Wade CS, Millikan WJ. Muromonab CD-3: a review of its pharmacology, pharmacokinetics, and clinical use in transplantation. Pharmacotherapy 11(1), 26–37 (1991).
Chatenoud L, Baudrihaye MF, Chkoff N, Kreis H, Goldstein G, Bach J-F. Restriction of the human in vivo immune response against the mouse monoclonal antibody OKT3. J. Immunol. 137(3), 830–838 (1986).