KB-1151

9D8-hIgG1

12157

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Background of 9D8-hIgG1

Fibrinogen-like protein 2 (FGL2) is a membrane-bound or secreted protein expressed by macrophages, T cells, and tumor cells that has coagulation activity or immune-suppressive functions. FGL2 promotes mammary tumor progression by promoting tumor angiogenesis or inducing epithelial-to-mesenchymal transition. 9D8-hlgG1 is a monoclonal antibody that only binds FGL2.

Specifications

Catalog Number	KB-1151
Antibody Name	9D8-hIgG1
Isotype	Human IgG1,kappa
FC Muations	Wild Type
Target	FGL2
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	ELISA
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Marazzi, S. et al. Characterization of human fibroleukin, a fibrinogen-like protein secreted by T lymphocytes. J. Immunol. 161, 138–147 (1998).
McGilvray, I. D. et al. Murine hepatitis virus strain 3 induces the macrophage prothrombinase fgl-2 through p38 mitogen-activated protein kinase activation. J. Biol. Chem. 273, 32222–32229 (1999).