KB-1192

ABBV011-hIgG1

45306

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Background of ABBV011-hIgG1

Seizure-related homolog protein 6 (SEZ6) is a cell surface protein expressed in SCLC, with normal tissue expression restricted to the brain and eye making it a rational therapeutic target. ABBV-011 is proposed to target SEZ6-expressing tumor cells with high affinity and release the calicheamicin payload intracellularly to induce cell death.

Specifications

Catalog Number	KB-1192
Antibody Name	ABBV011-hIgG1
Isotype	Human IgG1,kappa
FC Muations	Wild Type
Target	SEZ6
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	FACS
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Morgensztern D, Ready N, Johnson ML, Dowlati A, Choudhury N, Carbone DP, Schaefer E, Arnold SM, Puri S, Piotrowska Z, Hegde A, Chiang AC, Iams W, Tolcher A, Nosaki K, Kozuki T, Li T, Santana-Davila R, Akamatsu H, Murakami H, Yokouchi H, Wang S, Zha J, Li R, Robinson RR, Hingorani P, Jeng EE, Furqan M. A Phase I First-in-Human Study of ABBV-011, a Seizure-Related Homolog Protein 6-Targeting Antibody-Drug Conjugate, in Patients with Small Cell Lung Cancer. Clin Cancer Res. 2024 Nov 15;30(22):5042-5052.