KB-1275

AMG305-CDH3-hIgG1

12271

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Background of AMG305-CDH3-hIgG1

AMG 305 is a pioneering BiTE庐 (bispecific T cell engager) molecule that simultaneously binds to both P-cadherin (CDH3) and mesothelin (MSLN) to exert potent cytotoxic effects. Immunohistochemistry analysis reveals that CDH3 and MSLN are co-expressed in various types of solid tumors. However, in normal tissues, immunostaining demonstrates a lower occurrence of overlapping co-expression compared to the expression of either one of the targets alone. AMG 305 employs an avidity-based mechanism to activate T cells, enabling them to selectively eliminate CDH3+MSLN+ tumor cells while displaying limited activity against normal cells expressing only one of the target antigens.

Specifications

Catalog Number	KB-1275
Antibody Name	AMG305-CDH3-hIgG1
Isotype	Human IgG1,kappa
FC Muations	Wild Type
Target	CDH3
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	FACS
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

AMG 305, a dual targeting BiTE庐molecule with selective activity for solid tumors that co-express CDH3 and MSLN