KB-1318

AntiCLDN6-hIgG1

45490

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Background of AntiCLDN6-hIgG1

Claudin-6 (CLDN6) is a member of the claudin family, which plays a crucial role in the formation and maintenance of tight junctions (TJs) in epithelial and endothelial cells. These tight junctions are essential for the barrier function of tissues, controlling the passage of molecules and ions through the space between cells. CLDN6, like other claudins, is involved in various cellular processes, including cell adhesion, polarity, and differentiation. Its expression and function have been studied in the context of development, normal tissue function, and disease, particularly cancer.

Specifications

Catalog Number	KB-1318
Antibody Name	AntiCLDN6-hIgG1
Isotype	Human IgG1,kappa
Target	CLDN6
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	FACS
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Singh AB, Uppada SB and Dhawan P: Claudin proteins, outside-in signaling, and carcinogenesis. Pflugers Arch. 469:69–75. 2017.
English DP and Santin AD: Claudins overexpression in ovarian cancer: Potential targets for clostridium perfringens enterotoxin (CPE) based diagnosis and therapy. Int J Mol Sci. 14:10412–10437. 2013.