KB-1188

APL1020-001-hIgG1

12189

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Background of APL1020-001-hIgG1

The coinhibitory molecule B7-H4, an important member of the B7 family, is abnormally expressed in tumors, inflammation and autoimmune diseases. B7-H4 negatively regulates T cell immune response and promotes immune escape by inhibiting the proliferation, cytokine secretion, and cell cycle of T cells. Moreover, B7-H4 plays an extremely important role in tumorigenesis and tumor development including cell proliferation, invasion, metastasis, anti-apoptosis, etc.

Specifications

Catalog Number	KB-1188
Antibody Name	APL1020-001-hIgG1
Isotype	Human IgG1,kappa
FC Muations	Wild Type
Target	B7H4
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	ELISA
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Y. Kamimura et al. Possible involvement of soluble B7–H4 in T cell-mediated inflammatory immune responses. Biochem. Biophys. Res. Commun.(2009)
D. Darmochwal-Kolarz et al. The expression of B7–H1 and B7–H4 co-stimulatory molecules on myeloid and plasmacytoid dendritic cells in pre-eclampsia and normal pregnancy. J. Reprod. Immunol.(2013)