KB-1298

Aprutumab

52698

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Background of Aprutumab

Fibroblast growth factor receptor (FGFR) 2 is a transmembrane receptor tyrosine kinase with a key role in tissue repair and embryonic development. Aberrations leading to constitutive activation or overexpression of FGFR2, including gene amplification, gene fusions, and single nucleotide polymorphisms, have been identified in many cancer types, including triple-negative breast cancer, pancreatic, esophageal, hepatocellular, colorectal, ovarian, gastric, non-small-cell lung cancer (NSCLC), and glioma. Aprutumab (BAY 1179470) is a fully human FGFR2 monoclonal antibody, which binds to the FGFR2 isoforms FGFR2-IIIb and FGFR2-IIIc.

Specifications

Catalog Number	KB-1298
Antibody Name	Aprutumab
Isotype	Human IgG1, kappa
FC Muations	Wild Type
Target	FGFR2
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	ELISA
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Wesche J, Haglund K, Haugsten EM. Fibroblast growth factors and their receptors in cancer. Biochem J. 2011;437(2):199–213. doi: 10.1042/bj20101603.
De Moerlooze L, Spencer-Dene B, Revest JM, Hajihosseini M, Rosewell I, Dickson C. An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal–epithelial signalling during mouse organogenesis. Development. 2000;127(3):483–492.