Ba/F3-EGFR-B2M-HLA-A1101-Cell-Line

B2M, also known as β2 microglobulin, is a component of MHC class I molecules and expressed on nearly all nucleated cell. B2M noncovalently lies beside α3 heavy chain of MHC class I molecules on the cell surface without transmembrane region. HLA-A belongs to the HLA class I heavy chain paralogues. HLA-A is a heterodimer consisting of a heavy chain and a light chai. The heavy chain is anchored in the membrane. HLA-A plays a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen so that they can be recognized by cytotoxic T cells. They are expressed in nearly all cells. HLA-A is a Protein Coding gene. Diseases associated with HLA-A include Severe Cutaneous Adverse Reaction and Birdshot Chorioretinopathy. Among its related pathways are SARS-CoV-2 Infection and Infectious disease. Ba/F3 cell, a murine interleukin-3 dependent pro-B cell line, is a popular system for exploring both kinases and their inhibitors, because some protein kinases can render the Ba/F3 cells to be depended on the activation of the kinases instead of IL-3 supplement, while their inhibitors can antagonize the kinase-dependent growth effects.