IL21R (Interleukin 21 Receptor) is a Protein Coding gene. Diseases associated with IL21R include Immunodeficiency 56 and Ige Responsiveness, Atopic. Among its related pathways are Cytokine Signaling in Immune system and IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types. The protein encoded by the IL21R (interleukin 21 receptor) gene is a cytokine receptor for interleukin 21 (IL21), which belongs to the type I cytokine receptor, and has been shown to form a heterodimeric receptor complex with a common γ chain, which is a receptor subunit also shared by the interleukin 2, 4, 7, 9 and 15 receptors. This receptor mediates the growth-promoting signaling of IL21 and is important for the proliferation and differentiation of T cells, B cells, and NK cells. Ligand binding of this receptor results in the activation of a variety of downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. For example, by promoting the proliferation and development of Tfh and Th17 cells, balancing helper T cell subsets, inducing B cell generation and differentiation into plasma cells, and enhancing immunoglobulin production. These effects are mainly mediated by the activation of JAK/STAT, MAPK and PI3K pathways. In addition, there are studies examining the association between genetic variants in WSB1 and IL21R and Th2 immune responses during childhood A. lumbricoides infection suggest that the WSB1/IL21R pathway may provide a potential target for the treatment of Th2-mediated diseases.
Ba/F3 cell, a murine interleukin-3 dependent pro-B cell line, is a popular system for exploring both kinases and their inhibitors, because some protein kinases can render the Ba/F3 cells to be depended on the activation of the kinases instead of IL-3 supplement, while their inhibitors can antagonize the kinase-dependent growth effects.
