KB-1430

BA001-hIgG1

45684

Background of BA001-hIgG1

CD137, also recognized as 4-1BB, stands as a member of the TNFR superfamily denoted TNFRSF9. Initially identified as a costimulatory receptor exerting its influence on primed T cells, CD137's expression extends beyond the T cell lineage to encompass various leukocyte types. Of significance, CD137 assumes a pivotal role in activated T cells previously exposed to TCR-CD3 (signal 1) and reliant on CD28 (signal 2) to achieve robust surface expression of CD137. Upon ligation with its natural ligand, CD137L (4-1BBL), or through the engagement of an agonist monoclonal antibody, CD137 bestows upon T cells costimulatory signals.

Specifications

Catalog Number	KB-1430
Antibody Name	BA001-hIgG1
Isotype	Human IgG1,lambda
Target	CD137
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	ELISA
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Melero, I. et al. Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: Synergy with the CD28 co-stimulatory pathway. Eur. J. Immunol. 28, 1116–1121 (1998).
Etxeberria, I., Glez-Vaz, J., Teijeira, Á. & Melero, I. New emerging targets in cancer immunotherapy: CD137/4-1BB costimulatory axis. ESMO open 4 e000733 (2020).
Somekh, I. et al. CD137 deficiency causes immune dysregulation with predisposition to lymphomagenesis. Blood 134, 1510–1516 (2019).

Use License Agreement

Research Use Only.

Not for use in diagnostic procedures or therapeutic applications.