KB-1630

EU103-hIgG4-S228P

46786

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Background of EU103-hIgG4-S228P

VSIG4 is a type I transmembrane protein with a molecular weight of approximately 45 kDa. It consists of an extracellular domain containing a V-type and a C2-type immunoglobulin domain, a transmembrane domain, and a cytoplasmic domain. The gene is located on the X chromosome and is predominantly expressed in tissue-resident macrophages, including those found in the thymus, liver, adipose tissue, and alveoli. EU103 is a humanized monoclonal antibody targeting V-set and immunoglobulin domain-containing protein 4 (VSIG4), primarily associated with the modulation of tumor-associated macrophages (TAMs) in the cancer microenvironment.

Specifications

Catalog Number	KB-1630
Antibody Name	EU103-hIgG4-S228P
Isotype	Human IgG4-S228P,kappa
FC Muations	Wild Type
Target	VSIG4
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	ELISA
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Combination therapy with anti-VSIG4 and anti-PD-L1 suppress growth of tumor via conditioning of tumor microenvironment
Targeting VSIG4, a novel macrophage checkpoint, repolarizes suppressive macrophages which induces an inflammatory response in primary cell in vitro assays and fresh human tumor cultures