KB-1036

GK1.5-mIgG2a

12071

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Background of GK1.5-mIgG2a

GK1.5 is a mIgG2a mAb that recognizes the mouse CD4 Ag. The CD4 antigen is a membrane glycoprotein that belongs to the immunoglobulin superfamily. It is found on the cell surface and has a molecular weight of 55 kDa. CD4 acts as a co-receptor, working together with the T cell receptor (TCR) to interact with class II MHC molecules presented by antigen presenting cells (APC). It is expressed on the majority of thymocytes, most helper T cells, a subset of NK-T cells, and to a lesser extent, on dendritic cells and macrophages. CD4 plays a crucial role in the development and optimal functioning of mature T cells.

Specifications

Catalog Number	KB-1036
Antibody Name	GK1.5-mIgG2a
Isotype	Mouse IgG2a,kappa
FC Muations	Wild Type
Target	Mouse-CD4
Species Reactivity	Mouse
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	ELISA
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Comparison of GK1.5 and chimeric rat/mouse GK1.5 anti-CD4 antibodies for prolongation of skin allograft survival and suppression of alloantibody production in mice