KB-1485

hAb01-hIgG4-S228P

45780

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Background of hAb01-hIgG4-S228P

The thyroid stimulating hormone receptor (TSHR) is a crucial G protein-coupled receptor primarily located on the surface of thyroid epithelial cells. It plays a vital role in mediating the effects of thyroid stimulating hormone (TSH), which is essential for the synthesis and secretion of thyroid hormones, including thyroxine (T4) and triiodothyronine (T3). The activity of TSHR is dependent on various post-translational modifications, such as N-glycosylation and palmitoylation, which are critical for its function. Upon binding with TSH, TSHR activates a signaling cascade through G proteins, particularly stimulating adenylate cyclase, leading to increased intracellular levels of cyclic adenosine monophosphate (cAMP). TSHR plays a critical role not only in normal physiological processes but also as a potential biomarker and therapeutic target in various thyroid-related diseases, providing essential insights for clinical diagnosis and treatment.

Specifications

Catalog Number	KB-1485
Antibody Name	hAb01-hIgG4-S228P
Isotype	Human IgG4-S228P, kappa
Target	TSHR
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	FACS
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Thyrotropin-Blocking Autoantibodies and Thyroid-Stimulating Autoantibodies: Potential Mechanisms Involved in the Pendulum Swinging from Hypothyroidism to Hyperthyroidism or Vice Versa.