KB-1087

Iladatuzumab

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Background of Iladatuzumab

CD79B is a cell-surface antigen expressed on mature B cells but absent on plasma cells. A majority of mature malignancies of B-cell origin, including non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia, express CD79B and demonstrate rapid internalization of anti-CD79B antibodies. Iladatuzumab (MCDS0593A) is a humanized IgG1 monoclonal antibody against human CD79B. Iladatuzumab can be used to synthesize antibody-drug conjugates (ADC) Iladatuzumab vedotin, which has the potential for B-cell non-Hodgkin lymphoma (B-NHL) research.

Specifications

Catalog NumberKB-1087
Antibody NameIladatuzumab
IsotypeHuman IgG1,kappa
FC MuationsWT
TargetCD79b
Species ReactivityHuman
Host Cell LineEXPI CHO
Purification MethodAffinity purified
Concentration>2 mg/mL
Formulation50 mM sodium citrate,150mM NaCl,pH5.5
Purity>95% by SDS-PAGE and SEC-HPLC
ValidationFACS
Endotoxin Level<0.2 EU/mg as determined by the LAL method
Sterility0.2μm filtered
StorageIt is recommended that the protein should be aliquoted for optimal storage.
Avoid repeated freeze-thaw cycles.
StabilityStable for twelve months from date of receipt when stored at -20°C to -80°C;
Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

  1. Alex F Herrera, et al. Anti-CD79B Antibody-Drug Conjugate DCDS0780A in Patients with B-Cell Non-Hodgkin Lymphoma: Phase 1 Dose-Escalation Study. Clin Cancer Res. 2022 Apr 1;28(7):1294-1301.
  2. Louise Conilh, et al. Payload diversification: a key step in the development of antibody-drug conjugates. J Hematol Oncol. 2023 Jan 17;16(1):3. 
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