KB-1502

L7H6-hIgG4-S228P-GLP-1

46732

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Background of L7H6-hIgG4-S228P-GLP-1

GIP-R is a member of the class B family of G protein-coupled receptors. It is found on beta cells in the pancreas, where it acts as the receptor for the hormone Gastric inhibitory polypeptide (GIP). L7H6-hIgG4-S228P-GLP-1, developed by GrandMed Biopharma, is a dual-target drug for GIPR (glucose-dependent insulinotropic polypeptide receptor) and GLP-1R (glucagon-like peptide-1 receptor). It has the functions of suppressing appetite and reducing fat accumulation. The proposed indications are obesity, diabetes, and non-alcoholic steatohepatitis (NASH).

Specifications

Catalog Number	KB-1502
Antibody Name	L7H6-hIgG4-S228P-GLP-1
Isotype	Human IgG4-S228P, kappa
Target	GIPRxGLP-1
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	ELISA
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Stoffel M, Fernald AA, Le Beau MM, Bell GI (August 1995). "Assignment of the gastric inhibitory polypeptide receptor gene (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization". Genomics. 28 (3): 607–609..
Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors". Recept. Channels. 8 (3–4): 179–188.