CD73, also known as NT5E, CD73 (ecto-5'-nucleotidase) is a novel immunoinhibitory protein that plays a key role in tumor growth and metastasis. Its main function is to convert extracellular ATP to immunosuppressive adenosine in concert with CD39 in normal tissues to limit genes. excessive immune response. Inducible expression of CD73 and other adenosinergic molecules on cancer and host cells sustains the immunosuppressive tumor microenvironment by affecting multiple aspects of the immune response. It is an ideal therapeutic target for cancer treatment, especially with conventional therapy and/or other immune checkpoint inhibitors. Research has shown that regulatory T cells can express CD73 and inhibit T cell responses via the production of adenosine.
PD-L1, also called human programmed cell death ligand 1, is a transmembrane protein that plays a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease, virus infection, and cancer. PD-L1 binds to its receptor PD-1 on activated T cells, B cells, and myeloid cells, to modulate activation or inhibition. Upregulation of PD-L1 can allow the cancer cell to evade the host immune system.
