KB-1229

Nelistotug

52682

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Background of Nelistotug

Immune checkpoint blockade has become a promising therapeutic approach to reverse immune cell exhaustion. Coinhibitory CD96 and T-cell immunoglobulin and ITIM domain (TIGIT), together with costimulatory CD226, bind to common ligand CD155. The balancing between three receptors fine-tunes immune responses against tumors. High levels of TGF-β1 in HCC patients up-regulated CD96 expression and dynamically changed the balance between CD96, TIGIT and CD226 in NK cells. Nelistotug antibody can block CD96-CD155 interaction, restore NK cell immunity to tumor by reversing NK cell exhaustion, and promote anti-tumor response of CD8+ TIL.

Specifications

Catalog Number	KB-1229
Antibody Name	Nelistotug
Isotype	Human IgG1, kappa
FC Muations	Wild Type
Target	CD96
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	FACS
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Yumeng Wang , Congwen Wang , Junjun Qiu , Xinyu Qu , Jing Peng , Chong Lu , Meng Zhang , Mingxing Zhang , Xingling Qi , Guiling Li , Keqin Hua . Targeting CD96 overcomes PD-1 blockade resistance by enhancing CD8+ TIL function in cervical cancer. Immunother Cancer. 2022 Mar;10(3):e003667.
Haoyu Sun , Qiang Huang , Mei Huang , Hao Wen , Renyong Lin , Meijuan Zheng , Kun Qu , Kun Li , Haiming Wei , Weihua Xiao , Rui Sun , Zhigang Tian , Cheng Sun. Human CD96 Correlates to Natural Killer Cell Exhaustion and Predicts the Prognosis of Human Hepatocellular Carcinoma. Hepatology.2019 Jul;70(1):168-183.