KB-1757

Ozoralizumab

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Home » Antibodies » Ozoralizumab

Background of Ozoralizumab

Ozoralizumab (ATN-103) is an anti-TNFa humanized antibody. Ozoralizumab represents a humanized trivalent nanobody complex composed of two anti-human TNFa nanobodies and an anti-human serum albumin (HSA) nanobody. Ozoralizumab holds potential for utilization in the research of arthritis.

Specifications

Catalog NumberKB-1757
Antibody NameOzoralizumab
IsotypeNanobody
FC MuationsN/A
TargetTNFaxHSA
Species ReactivityHuman
Host Cell LineEXPI CHO
Purification MethodAffinity purified
Concentration>2 mg/mL
Formulation50 mM sodium citrate,150mM NaCl,pH5.5
Purity>95% by SDS-PAGE and SEC-HPLC
ValidationFACS|Reporter cell blocking|KD
Endotoxin Level<0.2 EU/mg as determined by the LAL method
Sterility0.2μm filtered
StorageIt is recommended that the protein should be aliquoted for optimal storage.
Avoid repeated freeze-thaw cycles.
StabilityStable for twelve months from date of receipt when stored at -20°C to -80°C;
Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

  1. Kratz F, Elsadek B (July 2012). "Clinical impact of serum proteins on drug delivery". J Control Release. 161 (2): 429-45. doi:10.1016/j.jconrel.2011.11.028.
  2. "Notification of Approval to Manufacture and Market Nanozora® 30mg Syringes for S.C. Injection, a Therapy for Rheumatoid Arthritis, in Japan Japan's First NANOBODY® Therapeutic" (Press release). Taisho Pharmaceutical Holdings. September 26, 2022.
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