KB-1212

RG6102-TFRC-hIgG1

12215

Home » Antibodies » RG6102-TFRC-hIgG1

Background of RG6102-TFRC-hIgG1

RG6102 is a bispecific 2+1 monoclonal antibody (mAb) under development for the treatment of Alz-heimer disease (AD). It combines the anti-amyloid beta antibody gantenerumab with a transferrin receptor 1-binding “Brain Shuttlemodule”, enabling active receptor-mediated transport across the blood-brain barrier.

Specifications

Catalog Number	KB-1212
Antibody Name	RG6102-TFRC-hIgG1
Isotype	Human IgG1,kappa
Target	TFRC
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	FACS
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Model-informed development of RG6102, an amyloid-targeting investigational drug with enhanced brain penetration properties.