KB-1122

Rituximab

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Background of Rituximab

Rituximab is a human/murine chimeric, glycosylated immunoglobulin (Ig) G1-κmAb containing murine light- and heavy-chain variable region sequences, and human kappa and human IgG1 constant region sequences. Rituximab has specific affinity for the B-lymphocyte transmembrane protein, CD20, which is expressed on normal B cells (excluding stem cells, pro-B cells, and plasma B cells) and on most malignant B cells.

Specifications

Catalog NumberKB-1122
Antibody NameRituximab
IsotypeHuman IgG1,kappa
FC MuationsWild Type
TargetCD20
Species ReactivityHuman
Host Cell LineEXPI CHO
Purification MethodAffinity purified
Concentration>2 mg/mL
Formulation50 mM sodium citrate,150mM NaCl,pH5.5
Purity>95% by SDS-PAGE and SEC-HPLC
ValidationCDC
Endotoxin Level<0.2 EU/mg as determined by the LAL method
Sterility0.2μm filtered
StorageIt is recommended that the protein should be aliquoted for optimal storage.
Avoid repeated freeze-thaw cycles.
StabilityStable for twelve months from date of receipt when stored at -20°C to -80°C;
Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

  1. Salles G, Barrett M, Foà R, Maurer J, O'Brien S, Valente N, Wenger M, Maloney DG. Rituximab in B-Cell Hematologic Malignancies: A Review of 20 Years of Clinical Experience. Adv Ther. 2017 Oct;34(10):2232-2273.
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