KB-1387

Secukinumab

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Home » Antibodies » Secukinumab

Background of Secukinumab

Secukinumab falls under the category of biologic medications, exerting its therapeutic action by specifically targeting interleukin-17A (IL-17A), a pivotal protein in the body implicated in the inflammatory cascade driving psoriasis. IL-17A, a cytokine of significance in the pathogenesis of psoriasis, orchestrates inflammation and fosters the generation of various cytokines and immune cells that actively contribute to the disease's progression. By impeding IL-17A, Secukinumab effectively mitigates inflammation, decelerates the proliferation of skin cells, and ameliorates the symptomatic manifestations of psoriasis. This multifaceted action aids in alleviating the symptoms associated with the condition.

Specifications

Catalog NumberKB-1387
Antibody NameSecukinumab
IsotypeHuman IgG1,kappa
FC MuationsK214R/D356E/L358M
TargetIL17A
Species ReactivityHuman
Host Cell LineEXPI CHO
Purification MethodAffinity purified
Concentration>2 mg/mL
Formulation50 mM sodium citrate,150mM NaCl,pH5.5
Purity>95% by SDS-PAGE and SEC-HPLC
ValidationELISA
Endotoxin Level<0.2 EU/mg as determined by the LAL method
Sterility0.2μm filtered
StorageIt is recommended that the protein should be aliquoted for optimal storage.
Avoid repeated freeze-thaw cycles.
StabilityStable for twelve months from date of receipt when stored at -20°C to -80°C;
Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

  1. Patel NU, Vera NC, Shealy ER, Wetzel M, Feldman SR (December 2017). "A Review of the Use of Secukinumab for Psoriatic Arthritis". Rheumatology and Therapy. 4 (2): 233–246.
  2. "FDA Approves Intravenous Variant of Secukinumab for Psoriatic Arthritis, Other Arthritis Types". HCP Live. 6 October 2023.
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