KB-1078

SHR1210-hIgG1

12097

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Background of SHR1210-hIgG1

SHR-1210 is a monoclonal antibody directed against programmed cell death 1 (PD-1), a protein found on the surface of specialized immune system cells called T-cells. When bound to its ligand, the programmed cell death ligand 1 (PD-L1), PD-1 suppresses the immune function of T-cells to ensure that they do not mistakenly attack healthy cells.

Specifications

Catalog Number	KB-1078
Antibody Name	SHR1210-hIgG1
Isotype	Human IgG1,kappa
FC Muations	Wild Type
Target	PD1
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	ELISA
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Ajani JA, D'Amico TA, Almhanna K, Bentrem DJ, Besh S, Chao J, et al Esophageal and esophagogastric junction cancers, version 1.2015. J Natl Compr Canc Netw 2015;13:194–227.
Ohashi S, Miyamoto S, Kikuchi O, Goto T, Amanuma Y, Muto M. Recent advances from basic and clinical studies of esophageal squamous cell carcinoma. Gastroenterology 2015;149:1700–15.
Huang J, Zhou Y, Zhang H, Qu T, Mao Y, Zhu H, et al A phase II study of biweekly paclitaxel and cisplatin chemotherapy for recurrent or metastatic esophageal squamous cell carcinoma: ERCC1 expression predicts response to chemotherapy. Med Oncol 2013;30:343.