KB-1706

TQC2938-hIgG2

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Home » Antibodies » TQC2938-hIgG2

Background of TQC2938-hIgG2

TQC2938 is a human anti-ST2 monoclonal antibody that targets the IL-33/ST2 axis, which has been found to be involved in regulate both Th2 low and Th2 high immune responses and may be a promising strategy for COPD.

Specifications

Catalog NumberKB-1706
Antibody NameTQC2938-hIgG2
IsotypeHuman IgG2,kappa
FC MuationsWild Type
TargetIL33R
Species ReactivityHuman
Host Cell LineEXPI CHO
Purification MethodAffinity purified
Concentration>2 mg/mL
Formulation50 mM sodium citrate,150mM NaCl,pH5.5
Purity>95% by SDS-PAGE and SEC-HPLC
ValidationELISA
Endotoxin Level<0.2 EU/mg as determined by the LAL method
Sterility0.2μm filtered
StorageIt is recommended that the protein should be aliquoted for optimal storage.
Avoid repeated freeze-thaw cycles.
StabilityStable for twelve months from date of receipt when stored at -20°C to -80°C;
Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

  1. X. Tian, R. Liu, L. Zhang, L. Qi, W. Xue, S. Wang, C. Sun, S. Sun, J. Zhang, D. Yu, A. Yang, and L. Mei. Safety, Tolerability, Pharmacokinetics, and Immunogenicity of a Human Monoclonal Antibody TQC2938 Targeting the IL-33/ST2 Axis in Healthy Chinese Adults [abstract]. Am J Respir Crit Care Med 2025;211:A3425.
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