KB-1519

U31784-hIgG1

45842

Background of U31784-hIgG1

Fibroblast Growth Factor Receptor 4 (FGFR4) is the fourth member of the FGF tyrosine kinase receptor family, which regulates cellular pathways involved in proliferation, differentiation, and survival. Fibroblast Growth Factor 19 (FGF19), a natural ligand for FGFR4, exhibits unique specificity for this receptor and plays a crucial role in regulating bile acid synthesis and hepatocyte proliferation in the normal liver. U3-1784 is a fully human IgG1 monoclonal antibody and an antagonist to the FGF19 ligand. It selectively targets FGFR4 without binding to FGFR1, FGFR2, or FGFR3, making it a promising therapeutic agent for conditions driven by the FGF19/FGFR4 pathway.

Specifications

Catalog Number	KB-1519
Antibody Name	U31784-hIgG1
Isotype	Human IgG1,lambda
Target	FGFR4
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	ELISA
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Preclinical Development of U3-1784, a Novel FGFR4 Antibody Against Cancer, and Avoidance of Its On-target Toxicity.
The impact of FGF19/FGFR4 signaling inhibition in antitumor activity of multi-kinase inhibitors in hepatocellular carcinoma