KB-1204

VSTB112-hIgG1

12203

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Background of VSTB112-hIgG1

VSTB112-hlgG1, a high affinity-specific humanized hlgG1 antibody against VISTA.VISTA(V-domain immunoglobulin suppressor of T cell activation)has become a current focus of research.VISTA not only acts as a ligand expressed on antigenpresenting cells, but also functions as a receptor on T cells.VISTA was identified as a V-set receptor that suppresses T cell-associated response for immune evasion and survival in several human cancers, such as prostate cancer, non-small cell lung cancer (NSCLC), and colorectal carcinoma.

Specifications

Catalog Number	KB-1204
Antibody Name	VSTB112-hIgG1
Isotype	Human IgG1,kappa
FC Muations	Wild Type
Target	VISTA
Species Reactivity	Human
Host Cell Line	EXPI CHO
Purification Method	Affinity purified
Concentration	>2 mg/mL
Formulation	50 mM sodium citrate,150mM NaCl,pH5.5
Purity	>95% by SDS-PAGE and SEC-HPLC
Validation	ELISA
Endotoxin Level	<0.2 EU/mg as determined by the LAL method
Sterility	0.2μm filtered
Storage	It is recommended that the protein should be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Stability	Stable for twelve months from date of receipt when stored at -20°C to -80°C; Stored at 2-8°C for one month without detectable loss of activity.

Characterization

Application

References

Huang Xing,Zhang Xiaozhen,Li Enliang et al. VISTA: an immune regulatory protein checking tumor and immune cells in cancer immunotherapy.[J] .J Hematol Oncol, 2020, 13: 83.
Villarroel-Espindola F, et al. Spatially resolved and quantitative analysis of VISTA/PD-1H as a novel immunotherapy target in human non-small cell lung cancer. Clin Cancer Res. 2018;24(7):1562-73.